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Science, in the broadest sense of the term, refers to any system of knowledge attained by verifiable means. In a more restricted sense, science refers to a system of acquiring knowledge based on empiricism, experimentation, and methodological naturalism, as well as to the organized body of knowledge humans have gained by such qualified retitle.

Scientists maintain that scientific investigation must adhere to the scientific method, a rigorous process for properly developing and evaluating natural explanations for observable phenomena based on reliable empirical evidence and neutral, unbiased independent verification, and not on arguments from authority or popular preferences. Science therefore bypasses supernatural explanations; it instead only considers natural explanations that may be falsifiable.

Fields of science are distinguished as pure science or applied science. Pure science is principally involved with the discovery of new truths with little or no regard to their practical applications. Applied science is principally involved with the application of existing knowledge in new ways, including advances in technology.

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DNA damage resulting in multiple broken chromosomes
DNA repair refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as UV light can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. Consequently, the DNA repair process must be constantly active so it can respond rapidly to any damage in the DNA structure.

The rate of DNA repair is dependent on many factors, including the cell type, the age of the cell, and the extracellular environment. A cell that has accumulated a large amount of DNA damage, or one that no longer effectively repairs damage incurred by its DNA, can enter one of three possible states: an irreversible state of dormancy, known as senescence; cell suicide, also known as apoptosis or programmed cell death; or unregulated cell division, which can lead to the formation of a tumor that is cancerous.

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Moon Dedal crater.jpg
Credit: Apollo 11 Crew, NASA

The far side of the Moon as photographed by the crew of Apollo 11. The largest crater pictured is the Daedalus crater.

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Carl Edward Sagan (November 9, 1934 – December 20, 1996) was an American astronomer, astrobiologist, and highly successful science popularizer. He pioneered exobiology and promoted the Search for Extra-Terrestrial Intelligence (SETI). He is world-famous for writing popular science books and for co-writing and presenting the award-winning 1980 television series Cosmos: A Personal Voyage, which was the most-watched PBS program until Ken Burns' The Civil War in 1990. A book to accompany the program was also published. He also wrote the novel Contact, the basis for the 1997 film of the same name starring Jodie Foster. During his lifetime, Sagan published more than 600 scientific papers and popular articles and was author, co-author, or editor of more than 20 books. In his works, he frequently advocated scientific skepticism, humanism, and the scientific method.

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